Like fellow desktop Twitter client TweetDeck, Lazyscope's support for real-time user streams eliminates the need for a refresh button, as updates flow into the application practically as they are posted to the microblogging network. The more active the users, the more frequent the updates, of course, as they cascade from the top down, simulating the stream in real time.
Lazyscope in Single Column View With User Streams Enabled
The option for a single column view that does not monopolize the screen is also important - as the content viewer (right pane) only opens when an article is selected, and closes when you are click the back arrow to return to the stream. In fact, the single column view is now the default view, giving you your screen real estate back.
Lazyscope in Full Expanded View
In addition to these two updates, Lazyscope, from the makers of Lazyfeed, has turned on keyboard shortcuts, letting you navigate the stream with arrow keys, reposting with the enter key, and my personal favorite, scrolling to the top of the screen with the space bar. As someone who uses keyboard short cuts all day long in Google Reader to go from story to story, doing the same in Lazyscope can make me even more efficient, and as they put it... more lazy.
If you haven't yet tried it, check out Lazyscope at http://www.lazyscope.com.